RNA Details
Disease Name
sclerosis
Tissue
skin
RNA Symbol
mir-7
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
homo sapiens
Detection Methods
PCR; in situ hybridization; immunoblotting etc.
Target
NA
Pathway
NA
PubMed ID
Title
MicroRNA-7 down-regulation mediates excessive collagen expression in localized scleroderma
Year
2013
Function
"Systemic or local down-regulation of mir-7 may contribute to the pathogenesis of lsc via the overexpression of alfa2(i) collagen, and serum mir-7 may be useful as a disease marker. Investigation of the regulatory mechanisms of lsc by mirna may lead to new treatments by the transfection into the lesional skin of this disease."